庞　媛-清华大学机械工程系

庞　媛

技术职务：清华大学机械工程系副研究员

办公电话：010-62798112

通讯地址：清华大学李兆基科技大楼A730

电子邮件：pangyuan31@tsinghua.edu.cn

2010.10-2013.09 东京大学，工学系研究科生物工程专业，工学博士学位

2011.06-2011.08 Wellman Center, Massachusetts General Hospital，哈佛医交换培养

2007.09-2010.06 重庆大学，化学化工药物化学专业，理学硕士学位

2003.09-2007.06 重庆大学，化学化工制药工程专业，工学学士学位

论文

[1]. GY. Li, JY. He, JH. Shi, XY. Li, LL. Liu, XL. Ge, WH. Chen, M. Yin, J. Jia, JL. Wang, SC. Lu, Y. Sakai, W. Sun, HK. Deng*, Y. Pang*. Bioprinting Functional Hepatocyte Organoids Derived from Human Chemically Induced Pluripotent Stem Cells to Treat Liver Failure. Gut, https://doi.org/ 10.1136/gutjnl-2024-333885;

[2]. C. Zhou, CR. Liu, ZD. Liao, Y. Pang*, W. Sun*. AI for biofabrication. Biofabrication, 17(2025) 17 012004; DOI 10.1088/1758-5090/ad8966;

[3]. H. Sun, Y. Wang, MH. Sun, XD. Ke, CC. Li, B. Jin, MC. Pang, YN. Wang, SZ. Jiang, LW. Du, SD. Du, SX. Zhong, HT. Zhao, Y. Pang, YL. Sun, ZY. Yang, HY. Yang, YL. Mao. Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer. Journal of Advanced Research, https://doi.org/10.1016/j.jare.2024.09.011;

[4]. YT. He, J. Li, L. Zhang, X. Zhu, Q. Fu*, Y. Pang*, Q. Liao. Nano zero-valent iron functioned 3D printing graphene aerogel electrode for efficient solar-driven biocatalytic methane production. Renewable Energy, 224(2024) 120146; https://doi.org/10.1016/j.renene.2024.120146;

[5]. JY. Ji, CJ. Zhao, C. Hua, L. Lu, Y. Pang*, W. Sun. 3D printing cervical implant scaffolds incorporated with drug-loaded carboxylated chitosan microspheres for long-term anti-HPV protein delivery. ACS Biomaterials Science & Engineering, 2024, 10, 1544−1553; https://doi.org/10.1021/acsbiomaterials.3c01594;

[6]. 孙铭浩，杨华瑜，孙乐家，孙航，张健刚，庞媛，余剑伟，王亚南，黄鹏羽，孙伟，毛一雷。3D 生物打印肿瘤模型诊治平台质量控制标准，DOI: 10.3781/j.issn.1000-7431.2023.2307-0389，肿瘤 TUMOR Vo1. 43，June 2023；

[7]. ZZ. Zhou, YT. Guo, CR. Liu, Y. Pang*, W. Sun. Engineering vascularized organotypic tissues via module assembly. International Journal of Extreme Manufacturing, 2024 6 012006;

[8]. ZZ. Zhou, Y. Pang*, JJ. Ji, JY. He, TK. Liu, LL. Ouyang, W. Zhang, XL. Zhang, ZG. Zhang, KT. Zhang, W. Sun*. Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies. Nature Reviews Immunology, https://doi.org/10.1038/s41577-023-00896-4；

[9]. TK. Liu, C. Zhou, JJ. Ji, XL. Xu, ZY. Xing, M. Shinohara, Y. Sakai, TP. Sun, XB. Feng, Z. Yu, Y. Pang*, W. Sun*. Spheroid on-demand printing and drug screening of endothelialized hepatocellular carcinoma model at different stages. Biofabrication, 15 (2023) 044102;

[10]. ZZ. Zhou, JY. He, Y. Pang*, W. Sun*. Reconstruction of tumor microenvironment via in vitro three-dimensional models. Biofabrication, 15 (2023) 032002;

[11]. YT. He, J. Li, L. Zhang, X. Zhu, Y. Pang*, Q. Fu*, Q. Liao. 3D-printed GA/PPy aerogel biocathode enables efficient methane production in microbial electrosynthesis. Chemical Engineering Journal, Volume 459, 1 March 2023, 141523;

[12]. D. Liu, Rr. Guo, SS. Mao, YJ. Huang, B. Wang, J. Dong, Y. Xin, RY. Xie, JZ. Shou, W. Sun, Y. Pang*, Y. Lu*. 3D magnetic field guided sunflower-like nanocatalytic active swarm targeting patients-derived organoids. Nano research, https://doi.org/10.1007/s12274-022-4851-z;

[13]. JY. He, C. Zhou, XL. Xu, ZZ. Zhou, M. Danoy, M. Shinohara, WJ. Xiao, D. Zhu, XY. Zhao, XB. Feng, YL. Mao, W. Sun, Y. Sakai, HY. Yang*, Y. Pang*. Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen-Permeable Microwell Device for Anti-Tumor Drug Evaluation. Advanced Healthcare Materials, https://doi.org/10.1002/adhm.202200863;

[14]. JY. Ji, CJ. Wang, Z. Xiong, Y. Pang*, W. Sun*. 3D-printed scaffold with halloysite nanotubes laden as a sequential drug delivery system regulates vascularized bone tissue healing. Materials Today Advances, 2022, 8(15), 100259, doi:10.1016/j.mtadv.2022.100259;

[15]. TK Liu#, C. Zhou#, YC. Shao, Z. Xiong, D. Weng*, Y. Pang*, W. Sun. Construction and application of in vitro alveolar models based on 3D printing technology. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers, Doi: 10.1016/j.cjmeam.2022.100025, (Back cover);

[16]. 周珍珍，庞媛*，孙伟*. 水凝胶疗法：为CAR-T细胞提供激活“驻地”. 科学通报, DOI: 10.1360/TB-2022-0415;

[17]. 周珍珍，庞媛*，孙伟*. 淋巴结-肿瘤双靶向型外泌体：双效协同肿瘤免疫治疗. 科学通报, DOI: 10.1360/TB-2022-0385;

[18]. 周珍珍，庞媛*，孙伟*. 提升类器官构建质量：生物打印还是手动操作？科学通报, DOI: 10.1360/TB-2022-0304;

[19]. 周珍珍，庞媛*，孙伟*. 纳米马达“驱动”T细胞深层浸润. 科学通报, doi: 10.1360/TB-2021-0986;

[20]. CJ. Zhao, JY. Ji, TJ. Y, J. Yang, Y. Pang*, W. Sun*. Affinity-controlled double-network hydrogel facilitates long-term release of anti-human papillomavirus protein. Biomedicines, 2021, 9(10), 1298; https://doi.org/10.3390/biomedicines9101298;

[21]. 周珍珍，庞媛*，孙伟*. 肿瘤类装配体“镜像”重现肿瘤微环境. 科学通报, 2021. doi: 10.1360/TB-2021-0831;

[22]. 周畅，赵晨佳，季静远，庞媛，孙伟. 展望个性化治疗：生物3D打印与药物筛选和递送. 中国普外基础与临床杂志 2021 年7 月第28 卷第7 期, 841-845;

[23]. TK. Liu, YC. Shao, ZT. Wang, YQ. Chen, Y. Pang*, D. Weng*, W. Sun*. 3D printing in vitro hydrogel microcarriers by alternating viscous-inertial force jetting. Journal of Visualized Experiments, (170), e62252, https://doi: 10.3791/62252;

[24]. YT. He, Q. Fu, Y. Pang*, Q. Li, J. Li, X. Zhu, RH. Lu, W. Sun, Q. Liao, U. Schröder. Customizable design strategies for high-performance bioanodes in bioelectrochemical systems. iScience 24, 102163, March 19, 2021. https://doi.org/10.1016/j.isci.2021.102163;

[25]. K. Changsorn^#, Y. Pang^#,*,H. Matsumoto, HF. Hong, P. Wüthrich, W. Sun, Y. Sakai. 3D perfusion culture of mouse insulinoma in macro-porous scaffolds enhanced insulin production response. The International Journal of Artificial Organs, 2022 Jan;45(1):96-102. http://dx.doi.org/10.1177/0391398820985515;

[26]. XL. Xu, X. Qian, CC. Cao, Y. Pang, H. Zhou, LZ. Zhu, Z. Wang, MQ. Pang, DF. Wu, WH. Yu, FY. Kong, DL. Shi, YT. Guo, XX. Su, W. Hu, J. Yan, XB. Feng, HN. Fan. Advances in the pharmacological treatment of hepatic alveolar echinococcosis: From laboratory to clinic. Frontiers in microbiology, doi: 10.3389/fmicb.2022.953846; PUBLISHED 08 August 2022;

[27]. JY. He, JL. Wang, Y. Pang, H. Y, XQ. Qin, K. Su, T. Xu, HZ. Ren. Bioprinting of a hepatic tissue model using human-induced pluripotent stem cell-derived hepatocytes for drug-induced hepatotoxicity evaluation. International journal of bioprinting, 2022, 8(3): 176-190;

[28]. RH. Lu, WH. Zhang, YT. He, SY. Zhang, Q. Fu, Y. Pang*, W. Sun*. Ferric ion crosslinking-based 3D printing of a graphene oxide hydrogel and its evaluation as a bio-scaffold in tissue engineering. Biotechnology and Bioengineering, 2021, 118(2): 1006-1012, http://dx.doi.org/10.1002/bit.27592. (Inside Cover Image);

[29]. FH. Xie, LJ Sun, Y. Pang, G. Xu, B. Jin, HF. Xu, X. Lu, YY. Xu, SD. Du, YN. Wang, S. Feng, XT. Sang, SX. Zhong, X. Wang, W. Sun, HT. Zhao, HB. Zhang, HY. Yang*, PY. Huang*, YL. Mao*. Three-dimensional bio-printing of primary human hepatocellular carcinoma for personalized medicine. Biomaterials, 2021, 265, 120416;

[30]. JY. He#, Y. Pang#, *, HY. Yang, K. Montagne, M. Shinohara, YL. Mao, W. Sun, Y. Sakai. Modular assembly–based approach of loosely packing co-cultured hepatic tissue elements with endothelialization for liver tissue engineering. Annals of Translational Medicine, 2020 8(21): 1400. http://dx.doi.org/10.21037/atm-20-1598；

[31]. HY. Yang^#, LJ. Sun^#, Y. Pang^#, DD. Hu^#, HF. Xu, SS. Mao, WB. Peng, YN. Wang, YY. Xu, YC. Zheng, SD. Du, HT. Zhao, TY. Chi, X. Lu, XT. Sang, SX. Zhong, X. Wang, HB. Zhang, PY. Huang*, W. Sun*, YL. Mao*. Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure. GUT, http://dx.doi.org/10.1136/gutjnl-2019-319960. (# Equal contribution)

[32]. SS. Mao, Y. Pang*, TK. Liu, YC. Shao, JY. He, HY. Yang, YL. Mao, W. Sun*. Bioprinting of In Vitro Tumor Models for Personalized Cancer Treatment : A Review. Biofabrication, 12 (2020) 042001; https://dx.doi.org/10.1088/1758-5090/ab97c0;

[33]. SS. Mao, JY. He, Y. Zhao, TK. Liu, FH. Xie, HY. Yang, YL. Mao, Y. Pang*, W. Sun*. Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing. Biofabrication, 12 (2020) 045014;

[34]. CJ. Zhao, ZT. Wang, C. Hua, JY. J, ZZ. Zhou, YC. Fang, D. Weng, L. Lu, Y. Pang*, W. Sun*. Design, Modeling and 3D Printing of Personalized Cervix Tissue Implant with Protein Release Function. Biomedical materials, 15 (2020) 045005, https://doi.org/10.1088/1748-605X/ab7b3b;

[35]. JY. Ji#, Y. Pang#, *, S. Sutoko, Y. Horimoto, W. Sun, T. Niino, Y. Sakai. Design, fabrication, and evaluation of polyglycolic acid modules with canals as tissue elements in cellular-assembly technology. Applied Science, 2020, 10(11), 3748; https://doi.org/10.3390/app10113748;

[36]. Y. Pang*, S. Sutoko, ZT. Wang, Y. Horimoto, K. Montagne, I. Horiguchi, M. Shinohara, D. Mathiue, T. Niino, Y. Sakai. Organization of liver organoids using Raschig ring-like micro-scaffolds and triple co-culture: Toward modular assembly-based scalable liver tissue engineering. Medical Engineering and physics, 76 (2020) 69–78. DOI: 10.1016/j.medengphy.2019.10.010;

[37]. SS. Mao, TK. Liu, HF. Hong, W. Sun, Y. Sakai, Y. Pang*. 3D fabrication of PCL micro-scaffolds with interconnected flow-channel and perfusion culture for in vitro construction of functional islet tissue. Proceedings - International Conference on Artificial Intelligence and Electromechanical Automation, AIEA 2020，DOI: 10.1109/AIEA51086.2020.00146;

[38]. LJ. Sun, HY. Yang, YN. Wang, XY. Zhang, B. Jin, FH. Xie, YK. Jin, Y. Pang, HT. Zhao, X. Lin, XT. Sang, HB. Zhang, F. Lin, W. Sun, PY. Huang, YL. Mao. Application of a 3D Bioprinted Hepatocellular Carcinoma Cell Model in Antitumor Drug Research. Frontiers in Oncology, 10:878. doi: 10.3389/fonc.2020.00878;

[39]. TK. Liu, Y. Pang*, ZZ. Zhou, R. Yao, W. Sun*. An integrated cell printing system for the construction of heterogeneous tissue models, Acta Biomaterialia, 2019, 95: 245-257;

[40]. Y. Pang^#,*, S. Sutoko^#, Y. Horimoto, D. Weng, K. Montagne, K. Komori, K. Takano, R. Shirakashi, M. Anzai, T. Niino, Y. Sakai. Biodegradable and hollowed micro-scaffolds for improved modular assembly-based tissue engineering: design, 3D fabrication, and feasibility in randomly packed perfusion culture. Biochemical Engineering Journal, 2019, 149 (15), 107239. (# Equal contribution);

[41]. TK. Liu, R. Yao, Y. Pang, W. Sun*. Review on Biofabrication and Applications of Heterogeneous Tumor Models. Journal of Tissue Engineering and Regenerative Medicine, 2019: 1-20. DOI: 10.1002/term.2949;

[42]. Y. Li, T. Zhang*, Y. Pang, L. Li, ZN. Chen, W. Sun*. 3D bioprinting of hepatoma cells and application with microfluidics for pharmacodynamic test of Metuzumab. Biofabrication, 2019, 11, 034102;

[43]. T. Zhang, F. Lin, T. Xu, L. Zhang, R. Yao, Y. Pang, SL. Mi, SH. Ma, W. Sun*. Bio-Manufacturing Research Center at Tsinghua University. Bio-Design and Manufacturing, 2019, 2, 137–143;

[44]. Y. Pang, SS. Mao, R. Yao, JY. He, ZZ. Zhou, L. Feng, KT. Zhang, SJ. Cheng and W. Sun*. TGF-β induced Epithelial-mesenchymal Transition in advanced cervical tumor model by 3D printing. Biofabrication, 10 (2018) 044102;

[45]. Y. Pang, F. Yang, Q. Gou, Z. Xia*. Rapid evaluation of antioxidants using a self-assembled capillary electrophoresis-chemiluminescence system. Basic & Clinical Pharmacology & Toxicology, 2017, 121 (Suppl. 5), 38-39;

[46]. Y. Pang, F. Yang, Q. Gou, Z. Xia*. Screening and evaluation of plasma protein binding effects to antioxidants in Herbal Ephedrae by capillary electrophoresis with chemiluminescence detection. Basic & Clinical Pharmacology & Toxicology, 2016, 119 (Suppl. 2), 35;

[47]. Y. Pang*, Y. Horimoto, S. Sutoko, K. Montagne, M. Shinohara, D. Mathiue, K. Komori, M. Anzai, T. Niino, Y. Sakai. Novel integrative methodology for engineering large liver tissue equivalents based on three-dimensional scaffold fabrication and cellular aggregate assembly. Biofabrication, 8 (2016) 035016;

[48]. Y. Pang, Y. Huang, F. Li, F. Yang, Z. Xia*. Rapid screening and evaluation of antioxidants in alkaloidal natural products by capillary electrophoresis with chemiluminescence detection. Analytical Methods, 2016, 8, 6545 - 6553;

[49]. Y. Pang*, S. Sutoko, Y. Horimoto, M. Anzai, T. Niino, Y. Sakai. Microfabrication and perfusion culture of new tissue Elements Possessing Hollow Structures with High Mechanical Strength towards Scaling-up to Implantable Liver. Tissue Engineering Part A, 2015, 21(S1), S3-S4;

[50]. Y. Pang*, S. Sutoko, Y. Horimoto, M. Anzai, T. Niino, Y. Sakai. An insight into in vitro construction of implantable liver: from “bottom up” integrated with “top down” aspects. Seisan Kenkyu, 2015, 67(3), 259-264;

[51]. T. Moro, Y. Itagaki, Y. Pang, I Horiguchi, Y. Sakai, T. Niino. Evaluation of scaffolds with plastic laser sintering of mixture of alkali-soluble filler. Seisan Kenkyu, 2015, 67(6), 617-623.

[52]. Y. Sakai*, Y. Pang, Y. Horimoto, M. Anzai, T. Niino. Tissue engineering scaffolds consisting of a macro-scale 3D flow channel network and small chambers. Bioindustry, 2014, 31(1), 45-50.

[53]. Y. Sakai*, Y. Pang, Y. Horimoto, M. Anzai, T. Niino. Design and organization of liver tissues based on oxygen supply. Journal of the heat transfer society of Japan, 2014, 53(222), 10-5.

[54]. Y. Pang*, K. Montagne, M. Shinohara, K. Komori, Y. Sakai. Liver tissue engineering based on aggregate assembly: efficient formation of endothelialized rat hepatocyte aggregates and their immobilization with biodegradable fibers. Biofabrication, 2012, 4(4), 045004. (Cover image);

[55]. Z. Xia*, Y. Pang, G. Zheng. Study on the Antioxidantive Biological Fingerprints of Astragalus Based on Capillary Electrophoresis. Chinese Journal of Analytical Chemistry, 2008, 36(12), 1646-50;

论著

[1]. Yuan Pang, Jingyuan Ji, Yasuyuki Sakai. “Design and organization of 3D tissues with branching/joining flow channel network based on oxygen transfer”. Chapter 10 Volume 1 “Emerging Technologies for Biofabrication and Biomanufacturing” in Emerging Technologies in Biophysical Sciences: A World Scientific Reference, World Scientific Publishing Company press, 2022-05 published;

[2]. 庞媛，孙伟，季静远，何剑宇. 第四章“3D打印在毒理学中的应用”. 《体外与预测毒理学》，北京大学医学出版社出版，2021.10;

[3]. 酒井康行, 厖媛, ステファニー・ウタミ・ストコ, 新野俊樹. 第8章“再生医療・創薬のための3次元細胞培養技術”，《階層的流路ネットワークを配備した組織再構築用担体》, 紀ノ岡正博監修, シーエムシー出版, 2018。

授权专利

[1]. 庞媛，郭育廷。细胞培养装置及其制备、培养方法。专利号：ZL 202410954219.9；

[2]. 孙伟，庞媛，周珍珍. 一种基于3D打印的T淋巴细胞扩增方法,专利号ZL 202010359007.8；

[3]. 庞媛，周珍珍，孙伟，何剑宇. 基于细胞团簇3D打印的血管化组织构建方法及其应用，申请中国专利，专利号：ZL2019112559175；

[4]. 孙伟、庞媛、季静远、赵晨佳、杨霞. 一种移植用载药人工直肠及其制备方法, 专利号ZL202010298728.2;

[5]. 庞媛，付乾，何玉婷，张武华，卢仁浩，谭勇. 3D打印梯度多孔氧化石墨烯三维微生物电极及其制备方法，专利号201811595184.5；

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